{"product_id":"the-pacemaker-channels-of-the-heart","title":"The Pacemaker Channels Of The Heart: From Reductionism To Systems Biology (Original PDF from Publisher)","description":"\u003cdiv class=\"prod-edition\"\u003e\n\u003cdiv class=\"field field--name-field-heading field--type-heading field--label-hidden field__item\"\u003e\n\u003cdiv class=\"columns small-12 medium-12 large-12 sidebar-full\"\u003e\n\u003cdiv class=\"elementor-element elementor-element-bbb44b8 elementor-widget elementor-widget-heading\" data-element_type=\"widget\" data-id=\"bbb44b8\" data-widget_type=\"heading.default\"\u003e\n\u003cdiv class=\"bundle--paragraph_component paragraph paragraph--type--paragraph-component paragraph--view-mode--default\"\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdiv class=\"columns small-12 medium-12 large-12 sidebar-full\"\u003e\n\u003ch1\u003eThe Pacemaker Channels Of The Heart\u003c\/h1\u003e\n\u003cbr\u003eBy Denis Noble\u003cbr\u003e\u003cbr\u003eIn The Pacemaker Channels of the Heart, Denis Noble chronicles the fascinating journey of his research into one of biology's most essential functions — the rhythmic beating of the heart. Written by the founder of mathematical heart modelling, this book traces scientific developments spanning over sixty-five years, from the pioneering 1960 heart rhythm model to the sophisticated integrative models of today. This journey follows the evolution of cardiac electrophysiology through the discovery of potassium and slow channels, analytical modelling, and the development of the electrocardiogram. Beyond its technical scope, the book describes a profound shift in biological thinking — from a reductionist, gene-centric view of life to a systems-based understanding of living organisms. In doing so, it addresses major philosophical and scientific debates surrounding the foundations of biology, offering a fresh perspective on why genes alone cannot account for the complexity of life. The book will be of great interest to researchers and students specialising in cardiology, as well as philosophers of science and more general readers, presenting a synthesis of rigorous research, theoretical innovation, and wider reflections on a storied career in the biological sciences. Contents: About the Author; Introduction; Discovery of Potassium Channels and the First Heart Cell Model; Discovery of Multiple Slow Channels; Analytical Mathematics of Excitable Cells; Insight into the T Wave of the Electrocardiogram; The Surprising Heart; Understanding Robustness in Biological Systems; The Physiome Project; 50 Years On; Systems Biology and The Music of Life; 65 Years On: Understanding Living Systems; Postscript: The Artist Disappears?; Glossary of Electrophysiology; Index;\u003ci class=\"a-icon a-icon-extender-expand\"\u003e\u003c\/i\u003e\n\u003cbr\u003e\u003ch3\u003eProduct Details\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003ePublisher ‏ : ‎ WSPC (EUROPE)\u003c\/li\u003e\n\u003cli\u003ePublication date ‏ : ‎ October 10, 2025\u003c\/li\u003e\n\u003cli\u003eLanguage ‏ : ‎ English\u003c\/li\u003e\n\u003cli\u003eISBN-10 ‏ : ‎ 1800618115\u003c\/li\u003e\n\u003cli\u003eISBN-13 ‏ : ‎ 978-1800618114\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"meducours","offers":[{"title":"Default Title","offer_id":42954536026210,"sku":"MED-AMB05558","price":15.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/9549\/6802\/files\/The-Pacemaker-Channels-Of-The-Heart.webp?v=1779379193","url":"https:\/\/meducourse.com\/products\/the-pacemaker-channels-of-the-heart","provider":"Meducourse","version":"1.0","type":"link"}